Combine mayonnaise, parsley, dill, garlic powder, salt, and pepper. Pat tilapia fillets dry with paper towels. Pour potato flakes into a pie pan or rimmed plate.
Preheat air fryer to 400°F. Spread 2 fillets with 1 Tbsp mayonnaise mixture each; dredge fillets in potato flakes, pressing gently to adhere. Spray air fryer with cooking spray. Arrange 2 coated fillets in air fryer and spray fillets with cooking spray. Air-fry until breading is crisp and fish is cooked through, about 10 minutes. Remove from air fryer and keep warm. Repeat process with remaining mayonnaise mixture, fillets, and potato flakes.
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